Ubiquinol is the reduced (active antioxidant) state of Co-Q10, the form produced by our cells and is significantly better absorbed as a supplement, particularly as we age. Jarrow Formulas QH-absorb is a proprietary enhanced stability formula, which has been clinically shown in humans to increase Co-Q10 levels up to 777% (6.14x) over baseline at 300 mg per day intake.
Ubiquinones are a series of homologous molecules that possess a quinone active center and an unsaturated fatty tail. Ubiquinones are so named because they’re widely distributed (i.e. ubiquitous) in nature and all over the human body. Structurally they’re similar to the menaquinones, like vitamin K2. The quinone group is sort of a courier for protons and electrons, which is the critical property that allows ubiquinones to act as antioxidants and as essential intermediates in energy generation. The fatty tail is composed of isoprenoid subunits, which can be five carbon building blocks that assist all living things biosynthesize critical components like immune modulators, crucial oils and hormones. The collection of isoprenoid units in the fatty tail is ceaselessly denoted in the name of specific ubiquinones. As an example, ubiquinone-10 is constituted of ten isoprenoid units. Ubiquinone-10 (aka CoQ10, coenzyme Q10, Q) is more regularly known as just “ubiquinone.” It’s because it’s the most prevalent ubiquinone in almost all mammals, including humans.
Supports heart function and antioxidant status*.
Utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorption. View larger.
Concern about CoQ10 levels is especially essential as a result of concern that cholesterol-lowering drugs (statins) work by inhibiting an enzyme that may be also answerable for CoQ10-ubiquinol biosynthesis. Because of this, any person taking statins may have reduced levels of CoQ10-ubiquinol.
What is Ubiquinol?
Ubiquinone and ubiquinol (aka ubiquinol-10, CoQ10-H2, QH, “reduced” CoQ10) are intimately related, as their names suggest. Inside the body, Q (ubiquinone) can only achieve its essential functions in energy production , cardiovascular health and antioxidant protection with the assistance of ubiquinol (QH).* If truth be told, all the benefits which have been attributed to CoQ10 necessitate QH involvement. The two do their work by shuttling electrons and protons back-and-forth, cyclically transforming from Q to QH and back again. In energy production, CoQ10 facilitates electron transfer within mitochondrial membranes to produce ATP, the body’s energy currency.* For antioxidant protection, QH is the “active antioxidant” Type of CoQ10. Because of this Q that has not been converted to QH is inactive as an antioxidant. Most likely this explains why circa 80-95 percent of total CoQ10 exists as QH in the blood and in healthy tissues that require its antioxidant function.*
Is Taking QH Better Than Taking Q?
CoQ10 is critically obtained from the diet, but it sounds as if that absorption of Q may entail conversion to QH. This conversion occurs as early as in the enterocytes, the absorptive cells in the intestine, and may facilitate the absorption process. Also under normal conditions there are enzymes that assist regenerate QH from Q, in the body. Unfortunately, aging and illness may end up in both a reduced ability to regenerate QH on account of decreased enzyme activity and a decreased ability to soak up Q itself, perhaps for a similar reason.
After about age 45, total Q levels and QH levels have a tendency to decline in more than a few critical tissues. Some physicians have even began to make use of blood and tissue ratios of QH to Q as a biomarker for age- and health-related oxidative stress. So it won’t come as a surprise that taking QH can give benefits that surpass those obtained from taking standard Q. But where’s the evidence?
QH-absorb Clinical Research
Eleven young, healthy adults ingested 100 mg of QH-absorb with food three times day by day (100 mg, t.i.d.) for fourteen days. Blood levels of total CoQ10, oxidized CoQ10 (Q) and reduced CoQ10 (QH) were measured at baseline and after fourteen days. This regimen of QH-absorb consumption resulted in a 777 percent mean increase of total CoQ10 levels in comparison to baseline and a 100 percent increase in plasma QH levels, the “active antioxidant” Type of CoQ10.
Two conclusions may also be drawn from these study results. First, it sounds as if that even young, healthy individuals can achieve benefits from taking ubiquinol (reduced CoQ10) from QH-absorb that surpass taking Q by myself. Prior to now, it was once presumed that only older individuals would get pleasure from taking QH-absorb as it’s known that starting about the age of 40, QH levels start to decrease in the body. Second, the 777 percent increase of total CoQ10 levels measured after taking QH-absorb is more than double the levels achieved by even the most productive Q supplements. This suggests QH-absorb is a minimum of twice as efficient in raising blood CoQ10 levels.*
Ubiquinol (QH) is Safe
Scientists have understood the value of QH for decades. It has just taken that long to determine a way to stabilize QH so it may be formulated into a nutritional supplement product. Toxicity studies have shown little concern with taking QH instantly, even at high doses. Plasma QH levels appear to plateau after two to four weeks of day by day ingestion and then return almost about baseline two weeks after day by day ingestion is discontinued. It also appears that supplementation with QH does not reduce CoQ10 biosynthesis in the body.
Jarrow Formulas QH-absorb is made with ubiquinol (QH) the more bioavailable, active-antioxidant Type of CoQ10. It utilizes the Q-absorb natural, proliposomal delivery system for enhanced absorption beyond that of QH by myself.
About Jarrow Formulas
Jarrow Formulas’ complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers may also be assured of purity, value and potency when choosing these products.
What’s in the Box
Jarrow Formulas QH-Absorb, 200mg, 30 Softgels.
Other Products from Jarrow Formulas:
Ubiquinol High Absorption Softgel: 2 Dosages: 100 & 200 mg
“Active Antioxidant” Type of Co-Q10
Ends up in Higher Blood Levels Than Co-Q10*: Especially for older consumers
Q-Absorb High-Absorption System